Brumbies halfback Tomas Cubelli will be rested from the Super Rugby clash with the Sunwolves, handing Michael Dowsett his first start of the season.
Coach Stephen Larkham is expecting Cubelli to be named in Argentina's national team before Tests against France and Italy in coming weeks.
Dowsett was given the nod ahead of Joe Powell, who was on Thursday earned surprise selection the the Wallabies' 39-man training squad for June's series against England.
Powell will come off the bench on Saturday night for the fifth time in 2016, alongside rookie Jordan Jackson-Hope, who made his debut in the Brumbies' win over the Melbourne Rebels a fortnight ago.
Ruan Smith has replaced Wallaby Ben Alexander at tighthead prop in the only change to the forwards after an impressive performance against the Rebels.
Robbie Coleman will make his return from a hamstring injury at inside centre, pushing James Dargaville back to the wing.
Saturday's match at GIO Stadium is the first between the Brumbies and Sunwolves, but the last before the competition breaks for the June international window.
Brumbies: Aidan Toua, Nigel Ah Wong, Tevita Kuridrani, Robbie Coleman, James Dargaville, Christian Lealiifano (capt), Michael Dowsett, Jarrad Butler, David Pocock, Scott Fardy, Sam Carter, Rory Arnold, Ruan Smith, Stephen Moore (capt), Scott Sio. Res: Josh Mann-Rea, Allan Alaalatoa, Leslie Leulua'iali'i-Makin, Tom Staniforth, Jordan Smiler, Joe Powell, Jordan Jackson-Hope, Lausii Taliauli.